Muscarinic acetylcholine receptors (mAChRs) are central to the modulation of neurotransmission in the human brain and are emerging as promising targets in the management of neuropsychiatric disorders.
Mouse neuroblastoma cells (Clone NIE-115) were grown in serum-free (defined) medium, defined medium supplemented with serum, and control medium to determine whether serum-free medium could substitute ...
The production of toxic Aβ peptides from amyloid precursor protein (APP) proceeds via the sequential cleavage of the extracellular domain by β-secretase, followed by an intramembrane cut by ...
Asceneuron SA, an emerging leader in the development of innovative small molecules for neurodegenerative diseases, has been awarded a research grant from The Michael J. Fox Foundation for Parkinson’s ...
In the December 2 Nature Chemical Biology, researchers led by Jeffrey Conn at Vanderbilt University, Nashville, Tennessee, report that they have developed a small molecule that not only boosts the ...
Acetylcholine is a chemical messenger, or neurotransmitter, that plays an important role in brain and muscle function. Imbalances in acetylcholine are linked with chronic conditions, such as Alzheimer ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 2 (January 11, 2011), pp. 621-625 (5 pages) The nicotinic acetylcholine receptor of skeletal muscle is ...
Adam Feuerstein is a senior writer and biotech columnist, reporting on the crossroads of drug development, business, Wall Street, and biotechnology. He is also a co-host of the weekly biotech podcast ...
In the US, the most common reason why someone needs a liver transplant is alcohol-associated liver disease (ALD)... | Microbiology ...
In recent years, nootropics, also called smart drugs, have gained popularity among people looking to improve their mental performance. Acetylcholine is a neurotransmitter, or brain chemical, that ...
A recent study posted to the bioRxiv* preprint server assessed the mechanism by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron and Alpha variants of concern (VOCs) inhibit ...
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