Amyloid precursor proteins (APPs) are evolutionarily conserved membrane glycoproteins that undergo complex proteolytic processing to yield fragments with diverse biological activities. Beyond their ...

Amyloid precursor protein (APP) is a type I transmembrane glycoprotein that undergoes complex routing through the secretory and endocytic pathways of neurons and non-neuronal cells. Proteolytic ...

Aη, or A-eta, made an initial splash when scientists reported that these fragments of amyloid precursor protein—products of a heretofore unknown cleavage—dampen neural activity. But how? The story ...

An estimated 50 million people worldwide have dementia, with Alzheimer's disease—accounting for more than 70%—being the representative neurodegenerative brain disorder. A Korean research team has, for ...

Care of patients with systemic immunoglobulin light chain (AL) amyloidosis has undergone transformative changes, leading to marked, steady progress in outcomes for patients over the past four decades.

Subtle biological changes linked to Alzheimer's disease may begin as early as the late 50s—decades before memory loss or other symptoms appear—according to new research from Mayo Clinic. A research ...

Carol Jennings, who volunteered as a research participant, has been posthumously recognised for her pivotal contribution to ...

In a recent study published in the journal PLOS Biology, researchers used mouse models to demonstrate that neurons were not the only source of abnormal amyloid β proteins contributing to the pathology ...

Leqembi and Kisunla don’t just reduce amyloid plaques that are implicated in Alzheimer’s disease. According to new research, the drugs boost levels of a healthy form of amyloid beta (Aβ42) protein in ...

Amyloid plaques are misfolded proteins aggregates between neurons, Alzheimer's disease illustration. [Artur Plawgo/Getty Images] Scientists have long known Alzheimer’s disease (AD) involves the build ...

A research group at Uppsala University has demonstrated that a new method for PET imaging of Alzheimer's disease is effective. The study was conducted in collaboration between the Department of Public ...