Type VI secretion systems (T6SS) are sophisticated nanomachines that bacteria employ to inject effector proteins directly into neighbouring cells. These systems are structurally reminiscent of ...

Scientists have discovered that Yersinia enterocolitica can regulate its type III secretion system in response to cell density, allowing the pathogen to alternate between virulent and ...

Many pathogenic bacteria use special secretion systems to deliver toxic proteins into host cells. Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich have determined the structure of a ...

Antimicrobial resistance (AMR) represents one of the most pressing challenges for global health, threatening the ...

Protein production is a multi-billion dollar industry, with applications in pharmaceuticals, industrial enzyme use (eg in laundry detergent), and biomaterials. Bacteria are receiving renewed interest ...

UPTON, NY — New details of the composition and structure of a needlelike protein complex on the surface of certain bacteria may help scientists develop new strategies to thwart infection. The research ...

Now Niederweis and colleagues at the University of Alabama at Birmingham describe the mechanism of secretion and trafficking of that toxin, TNT, which is the major cytotoxicity factor for the pathogen ...

Six years ago, researchers described the first toxin ever found for the deadly pathogen Mycobacterium tuberculosis. However, the mechanism for its secretion from the bacterium was unknown. Now, ...

Six years ago, Michael Niederweis, Ph.D., described the first toxin ever found for the deadly pathogen Mycobacterium tuberculosis. This toxin, tuberculosis necrotizing toxin, or TNT, became the ...

Swallow the wrong microbe, and you might end up in the hospital with a needle or two in your arm — and plenty of itty-bitty bacterial needles poking at you from the inside. That’s because many ...

You suddenly feel sick -- pathogenic bacteria have managed to colonize and spread in your body! The weapons they use for their invasion are harmful toxins that target the host's defense mechanisms and ...