Calcium signalling represents a fundamental process in cellular communication, orchestrating diverse physiological responses from muscle contraction to neurotransmission and gene regulation. At the ...

Calcium ions are essential for cells, but can be toxic in higher concentrations. A team of researchers has now designed and prepared a combination drug that kills tumor cells by modulating the calcium ...

In 2008 researchers at the Perelman School of Medicine at the University of Pennsylvania showed that mutations in two proteins associated with familial Alzheimer's disease (FAD) disrupt the flow of ...

In a recent study posted to the bioRxiv* preprint server, researchers investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein activity in terms of calcium ...

An estimated 1.3 billion people worldwide suffer from elevated blood pressure or hypertension. Calcium channel blockers are often used to lower a patient’s blood pressure by blocking calcium ions from ...

Mutations in a calcium ion channel anoctamin 5 (ANO5), commonly found in muscle cells, cause the debilitating disease called limb girdle muscular dystrophy 2L (LGMD2L). Characterized by progressive ...

Towards the end of 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared on the scene, and practically shut down the world for the next several months. Since then, a slow and ...

Researchers have discovered how an ion channel in the brain’s neurons has a kind of ‘molecular memory’, which contributes to the formation and preservation of lifelong memories. The researchers have ...

Transgenic tobacco leaves after 24 hours of green light exposure: a, plant with anion channel GtACR1; green light-induced membrane potential change (depolarization) is shown on the left. b, plant with ...

An atomic level analysis has revealed how two classes of calcium channel blockers, widely prescribed for heart disease patients, produce separate therapeutic effects through their actions at different ...