Cytokine signaling is thought to require assembly of multicomponent signaling complexes at cytoplasmic segments of membrane-embedded receptors, in which receptor-proximal protein kinases are activated ...

Hormones are chemical messengers that interact with receptors present on the surface of a cell membrane or with receptors that are located inside the cell, in the cytoplasm (cytoplasmic receptors).

Receptor such as protein kinases are proposed to work as sensors to initiate signaling cascades in higher plants. However, little is known about the precise functions of receptor such as protein ...

All cell lines used in this study were purchased from ATCC. COS-1 cells were maintained in DMEM supplemented with 10% fetal bovine serum. LNCaP and PC3 cells were maintained in RPMI1640 supplemented ...

Two landmark studies provide unprecedented structural insight into how plant immune receptors are primed -- and then activated -- to provide plants with resistance against microbial pathogens.

According to new research in the journal Immunity, T cells have a nuclear receptor doing something very odd - but very important - to help them fight pathogens and destroy cancer cells. This receptor, ...

This project will investigate how residues located in the cytoplasmic domain of NMDA receptors influence this receptor's function. Approaches include mutagenesis, protein expression in heterologous ...

Researchers have discovered that the opioid growth factor and its receptor, OGFr, a clinically important system with potent anti-tumor properties, has controlled entry from the cytoplasm to the ...

Q.H. Shen et al., "Nuclear activity of MLA immune receptors links isolate-specific and basal disease–resistance responses," Science, 315:1098–1103, 2007. (Cited in 76 papers) After staining the nuclei ...

Resistant plants are not unprepared for intruders. Their cells are supplied with receptors that detect danger, as well as a mobile crisis manager responsible for the rollout of the immune response. As ...

In this novel study, scientists investigate the molecular mechanism of the aryl hydrocarbon receptor in the aging process and the regulation of asthma in elderly patients Healthcare around the world ...