When chemists need to separate one chiral molecule from a mixture of enantiomers—for instance, when synthesizing potential drug molecules—they often turn to high-performance liquid chromatography ...

(A) Binding energies of (-)-morphine and (+)-morphine interacting with MOR. (B) Binding pocket residues of (-)-morphine and (+)-morphine in MOR, visualized from the extracellular side. (C) W293 ...

From 2001 to 2011, the US Food and Drug Administration approved 9 single-enantiomer drugs with racemic precursors. None showed pre-approval evidence of improved efficacy over the racemic precursor. We ...

Many chemical compounds exist in two variants, called enantiomers. These consist of the same elements but act as mirror images of each other. In reference to our hands, which are also mirror images, ...

Separations using tiny polymer-based devices could offer an alternative to chromatography for purifying of chiral compounds. Serena Arnaboldi of the University of Milan and coworkers initially ...

Enantiomers are two molecules with the same chemical composition, mirror images of each other, which do not overlap. Produced in equal quantities during a chemical reaction, they may exhibit opposite ...

New biocatalytic and chemocatalytic routes to chiral intermediates and developments in simulated-moving-bed and supercritical-fluid chromatography for resolving racemic mixtures. The prevalence of ...

Using a new method, scientists are better able to distinguish between mirror-image substances. This is important amongst others in drug development, because the two variants can cause completely ...

Single-enantiomer drugs account for nearly 40% of the global pharmaceutical market. The author analyzes the current market for single-enantiomer drugs, their role as a generic drug defense strategy, ...