Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

According to estimates, about a third of the world's population is infected with the single-celled parasite Toxoplasma gondii ...

Rapid plasma membrane resealing is essential for cellular survival. Earlier studies showed that plasma membrane repair requires Ca2+-dependent exocytosis of lysosomes and a rapid form of endocytosis ...

Living cells and tissues show a high capacity to absorb various chemical compounds from the surrounding environment. Although the absorption of small molecules is quite simple for cells and tissues, ...

image: To survive and fulfill their biological functions, cells need to take in material from their environment. In this process, proteins within the cell pull inward on its membrane, forming a pit ...

Endosomes are membrane-bound cytosolic vesicles with three major compartments namely early, late, and recycling endosomal compartments. Endosomes are the integral parts of the endocytic process, and ...

Each cell is separated from its environment by a membrane that protects the cell from the outside environment. However, this barrier can be overcome by certain chemicals that sustain the basic ...

Metastasis is leading cause of cancer death. The essential step of metastasis is invasion. The actin cytoskeleton plays a pivotal role in invasion and is closely linked to endocytosis process. We ...

Apolipoprotein E (ApoE) is kind of like a delivery service for the human brain. It supplies neurons with important nutrients, including with polyunsaturated fatty acids - which are building blocks of ...