Centromeres play virtually the same central role across the entire tree of life: They ensure the faithful segregation of chromosomes during cell division. Yet the striking diversity in centromere ...

Cancer does not develop overnight. It can take decades for cancer-promoting changes in the genome to eventually lead to the formation of a malignant tumor. Researchers at the German Cancer Research ...

Like all complex organisms, every human originates from a single cell that multiplies through countless cell divisions. Thousands of cells coordinate, move and exert mechanical forces on each other as ...

The integration of single-cell and spatial transcriptomics with advanced metabolic profiling tools has revolutionized the ...

HER2-positive gastric cancer accounts for a substantial proportion of advanced cases and has long been treated with HER2-targeted therapies. While trastuzumab deruxtecan has shown superior activity ...

Scientists at Nagoya University in Japan have identified the genes that allow an organism to switch between living as single cells and forming multicellular structures. This ability to alternate ...

Dissociating tissues into single cells is a core laboratory technique and vital for widely used applications such as next-generation sequencing or flow cytometry. Scientists who employ tissue ...

Researchers at Moffitt Cancer Center have developed a new way to predict how cancer cells evolve by gaining and losing whole chromosomes, changes that help tumors grow, adapt and resist treatment. In ...

Single-cell RNA-seq (scRNA-seq) has spent the past decade maturing into a foundational technology. Over that time, the technology has both laid the foundation for building cell atlases and allowed ...

A new platform combines rational protein design with continuous evolution to discover functional molecules more efficiently. In medicine and biotechnology, the ability to evolve proteins with new or ...