Peripheral primitive neuroectodermal tumors are part of a family of childhood tumors that includes Ewing's sarcoma. These tumors are collectively referred to as the Ewing's sarcoma family of tumors ...
Researchers have discovered a novel consequence of loss of the tumor protein p53 that promotes cancer development. The study suggests that multiplication of cancer cells in the absence of appropriate ...
Fig 1. Putative mechanisms of resistance to CDK4/6i. Cartoon shows G1 checkpoint kinases CDK4/6 coupled to D-cyclins promoting cell cycle progression through the G1-S transition by phosphorylating Rb ...
Scientists have developed a mathematical model that describes a key step in human cell division – and an important target for cancer treatment – in unprecedented detail. Using their model, the ...
In particular, Deng and his colleagues wanted to examine the effects of dysfunctional BRCA1 on the cell cycle. Deng says that hints from work conducted in other labs suggested that the level of BRCA1 ...
The research was published today in an advanced, online issue of the Proceedings of the National Academy of Sciences. The cell cycle, which allows cells to replicate their DNA and produce new cells, ...
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