A new CRISPR-based tool that is directly used on patients' cancer cells can identify genes and regulatory elements driving ...

Most cancers are not driven by a single gene mutation, but rather an accumulation of mutations that develop over the evolution of tumor growth. While mouse models are useful for identifying cancer ...

Please provide your email address to receive an email when new articles are posted on . NASHVILLE, Tenn. — An analysis of germline susceptibility to renal cell carcinoma revealed considerable ...

Forty-five years ago adult AL was incurable. Since then we have discovered the striking heterogeneity of AL and its importance in selecting therapy, resulting in cure of increasing numbers of patients ...

Genetic medicine is rapidly transforming the landscape of cancer research, offering novel strategies for treating malignancies beyond the capabilities of ...

The power of CRISPR became definitively clear when the first CRISPR-based gene therapy, Casgevy (exa-cel), won regulatory approvals for the treatment of sickle cell disease. But CRISPR’s applications ...

Hypermobile Ehlers–Danlos syndrome (hEDS) is one of the most common heritable connective tissue disorders. Early estimates have reported that this genetic disorder affects at least one in 5,000 ...

Within this large-scale study, published in Nature Communications, scientists examined genetic data linked to type 2 diabetes and blood pressure regulation. Both conditions frequently occur in the ...

Type 2 diabetes and high blood pressure share a genetic link, according to new research from the University of Surrey, U.K., ...

Polygenic indices related to the best-established social, psychological, and behavioural mortality risk phenotypes had the strongest associations with mortality.