Scientists are exploring ways to mimic the origins of human life without two fundamental components: sperm and egg. They are coaxing clusters of stem cells – programmable cells that can transform into ...

PAX6-dependent epithelial differentiation and developmental trajectories of the ocular surface are elucidated through single-cell RNA sequencing of hiPSC-derived ocular organoids. This study provides ...

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Under his microscope, Jun Wu could see several tiny spheres, each less than 1 millimetre wide. They looked just like human embryos: a dark cluster of cells surrounded by a cavity, and then another ...

Four teams have coaxed human stem cells to organize themselves into embryo-like forms. The advance could shed light on fertility. By Carl Zimmer In its first week, a fertilized human egg develops into ...

For decades, animal models have been the gold standard for preclinical testing of potential drugs. Yet, even the best animal models are not perfect. For example, small rodent species with engrafted ...

Animal models have long shaped how biomedical research is conducted. They have influenced how diseases are studied, how ...