Sepsis arises from a dysregulated host response to infection, in which an initial wave of pathogen‐induced inflammation becomes amplified by excessive production of reactive oxygen species (ROS).

Sepsis continues to be a significant cause of morbidity and mortality in hospitalized newborns and premature infants. The pathophysiology and disease state of sepsis appear to be similar between ...

The complement system represents a cornerstone of innate immunity, comprising a cascade of plasma proteins that, upon activation, facilitate pathogen clearance and coordinate inflammatory signalling.

Why do some people recover easily from bacterial infections while others rapidly deteriorate into life-threatening sepsis?

Like a poison pen, dying cells prick their neighbors with a lethal message. This may worsen sepsis, Vijay Rathinam and colleagues in the UConn School of Medicine report in the Jan. 23 issue of Cell.

A naturally-occurring protein in the human body could protect people from one of the world’s biggest killers – sepsis. The protein’s ability to reduce inflammation in a preclinical study raises hopes ...

Sepsis is a life-threatening condition triggered by the body’s extreme response to infection. It causes widespread inflammation, which can lead to tissue damage, organ failure and death. Thanks to ...

Neutropenic sepsis is a body-wide reaction that can occur when a person with an infection or injury also has a low level of immune cells called neutrophils. Neutropenic sepsis is a medical emergency ...

Bacterial infections can lead to the formation of abscesses - pockets of dead cells and debris surrounded by inflammatory immune cells. Bacteria multiply within abscesses, causing more inflammation ...