In the mammalian CNS, the principle excitatory neurotransmitter is L-Glutamate, which acts through G-protein coupled (metabotropic) receptors and ligand gated ion channels (ionotropic receptors).

The brain’s major excitatory neurotransmitter is glutamate. Glutamate, which is released from presynaptic vesicles, is the neurotransmitter which activates postsynaptic ligand-gated ion channel ...

Neuroanatomical and pharmacological evidence implicates glutamate transmission in drug-environment conditioning that partly controls drug seeking and relapse. Glutamate receptors could be targets for ...

This is a preview. Log in through your library . Abstract Changes in the morphology of dendritic spines are correlated with synaptic plasticity and may relate mechanistically to its expression and ...

New research show at the single cell level how an external stimulus sets off a molecular chain reaction in the transparent roundworm C. elegans, a process in which a single neurotransmitter ...

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG Binding Protein 2 (MECP2) gene. In mouse models of RTT, deficits in long-term potentiation (LTP) at Schaffer ...

An investigational, phase II study published in the scientific journal Nature Medicine demonstrates that for the first time in humans a drug that acts on certain proteins in the brain called mGlu2/3 ...