The locus coeruleus (LC) is a small, bilateral nucleus in the dorsal pons that serves as the main source of noradrenaline in the brain. Its widespread projections modulate arousal, attention, memory ...

A new study has identified a region in the brainstem, the structure connecting the brain to the spinal cord, that plays a crucial role in cognitive flexibility and the ability to adapt to changing ...

Inhibiting locus coeruleus input to the medial prefrontal cortex in mice impaired task performance, affected the tuning of single cortical neurons and disrupted population dynamics and encoding ...

Optogenetic stimulation of the locus coeruleus noradrenergic neurons can increase wakefulness, and high-frequency stimulation decreases noradrenaline levels and produces loss of muscle tone similar to ...

A tiny region in the brain works like a reset button that separates memory of one meaningful event from the next. Without this reset mechanism, moments could blur together and lead to the kinds of ...

Small and seemingly specialized, the brain's locus coeruleus (LC) region has been stereotyped for its outsized export of the arousal-stimulating neuromodulator norepinephrine. In a new paper and with ...

Long thought of as a generic alarm system, the locus coeruleus may actually be a sophisticated regulator of learning and behavior, according to a new review. Small and seemingly specialized, the brain ...

Norepinephrine-producing neurons in the locus coeruleus, a small nucleus in the brainstem, have been discovered to have two distinct types of cells that connect linearly via gap junctions - novel ...

The locus coeruleus is emerging as a major new area of research interest, with many important functions such as regulating our attention and sleep. Anyone with insomnia knows the impatience and ...