Penn State won the last matchup, 42-0, at Ford Field in 2023. The Nittany Lions are 7-point favorites in the latest Michigan State vs. Penn State odds, while the over/under for total points scored is 49.

Both teams enter on six-game losing streaks. The most recent victories for both squads came against FCS opponents back on Sept. 13, when MSU beat Youngstown State and the Nittany Lions defeated Villanova. Penn State has not beaten a Power Four team this year, while Michigan State's lone such victory is against 1-9 Boston College in double overtime.

Kaytron Allen and relentless defensive pressure drive Penn State football to their first win in two months at Michigan State.

In a matchup against the undefeated Crimson, Penn football fell 45-43 after a 53-yard field goal from Crimson kicker Kieran Corr in the final seconds of the game. Penn (5-4, 3-3 Ivy) had a strong offensive performance across the evening, with senior quarterback Liam O’Brien completing 80% of his passes, totaling 271 yards.

Harvard clinched a 45-43 win over Penn on Saturday in a nail-biting thriller with just seconds left on the clock. In a nail-biting thriller, junior kicker Kieran Corr drilled a game-winning 53-yard field goal to seal Harvard’s victory and a share of the Ivy League title.

Fort Wayne Carroll rode a 20-point fourth quarter to a 41-30 IHSAA Class 6A football regional championship win over Penn Friday night.

As memories of 2023’s triple-overtime loss still loomed among the Penn team, Harvard then methodically paced downfield, taking all the time remaining on the clock along with it. Finally, with two seconds left in the game, the Crimson set off a 23-yard kick straight through the uprights to seal a Homecoming heartbreak for the Quakers.