*Motivation:* In current proteome research, peptide sequencing is probably the most widely used method for protein mixture identification. However, this peptide-centric method has its own ...

When researchers perform peptide mass fingerprinting on gel slices, they typically use matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) spectrometers, such as Applied Biosystems' ...

Perhaps no tool has been as instrumental to the proteomics revolution as the mass spectrometer. With the ability to deconvolute highly complex mixtures over a wide range of abundance levels, these ...

All figures and photographic images will be published under a Creative Commons Attribution License (CCAL), which allows them to be freely used, distributed, and built upon as long as proper ...

MALDI remains a powerful tool for analyzing large biomolecules with minimal fragmentation. In this process, peptides or proteins are co-crystallized with a matrix on a metal plate. A laser pulse ...

Two-dimensional polyacrylamide gel electrophoresis (2D gel electrophoresis) is one of the earliest high-resolution proteomics techniques used for visualizing and separating complex protein mixtures.