The granule-exocytosis cytotoxicity pathway, by which cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells secrete perforin and granzymes to kill target cells, is crucial for host defence. But ...

As a part of our immune defenses, cytotoxic T cells – or killer T cells – seek out and destroy cells that are infected or cancerous. This process is essential for the body's defense against diseases.

We have a lot to thank our immune systems for, as they remain ever-vigilant to protect us from cancer and infections. But exactly how do immune cells avoid wiping themselves out while attacking ...

Peter Mac scientists are part of a research team that has determined the structure of a pore-forming protein used by the immune system to kill unwanted cells. The work was led by researchers in the ...

The scientists made the discovery by studying perforin, which is the protein responsible for the hole-punching. They found that perforin's attachment to the cell surface strongly depends on the order ...

Cancer cells are adept at escaping death. One of the ways in which cancer cells prevent death from fatal attacks by cytotoxic T lymphocytes (CTLs) is by efficiently repairing damage to their cell ...

New research reveals the mechanical processes used by T cells to kill cancer cells more efficiently. As a part of our immune defences, cytotoxic T cells -- or killer T cells -- seek out and destroy ...

Perforin-positive dendritic cells (perf- DCs) represent a minor subpopulation of myeloid DCs. Based on selective ablation of perf-DCs in radiation chimera, Reisner and colleagues demonstrate that ...

Research led by the University of Sydney, Australia, has uncovered an important driver of critical SARS-CoV-2 infections. In their paper, "A unique cytotoxic CD4+ T cell-signature defines critical ...

As a part of our immune defences, cytotoxic T cells – or killer T cells – seek out and destroy cells that are infected or cancerous. This process is essential for the body’s defence against diseases.