Numerous studies support a role of phosphatase and tensin homolog deleted from chromosome 10 (Pten) as a tumor suppressor gene that controls epithelial cell homeostasis to prevent tumor formation.

Barrett's esophagus is an acquired metaplastic abnormality in which the normal stratified squamous epithelium lining of the esophagus is replaced by an intestinal-like columnar epithelium. While in ...

Stratified squamous epithelia express the αvβ5 integrin, but in squamous cell carcinomas (SCCs) there is down-regulation of αvβ5 and up-regulation of αvβ6. To investigate the significance of this ...

Fragments of normal human adult vagina, when explanted onto glass slides gave rise to outgrowing sheets of pure epithelium, which had microscopic morphological features in common with normal vaginal ...

Squamous cell carcinoma (SCC) is a lethal cancer arising from the stratified epithelia of skin, esophagus, cervix, as well as the head and neck tissues. Genomic analysis of SCCs identified genomic ...

Researchers report a new molecular mechanisms regulating cellular fate of squamous cell carcinomas. Researchers at Kanazawa University report in EMBO Reports a new molecular mechanisms regulating ...