A common hallmark of viral genome replication is a high mutation rate, which can aid in their ability to evade new treatments and acquire resistance to once-effective antiviral medications. Now, a new ...

Using cryo-microscopy, researchers present a high-resolution structure of monkeypox virus DNA polymerase holoenzyme, a complex that plays a key role in the genome replication process of the virus. The ...

Nipah virus is a zoonotic virus harbored by fruit bats. It can be transmitted to pigs and humans, infect people through contaminated food, and can travel directly from person to person via droplets.

During viral reproduction, the influenza polymerase (top left, in blue) scans along the ribonucleoprotein helix to produce messenger RNA. Credit: Science Like a camera-shy teenager, influenza’s ...

To treat Ebola virus infections, researchers are taking a close look at a key piece of the virus: polymerase Polymerase is a viral protein that directs how Ebola virus replicates its genome as it ...

Researchers at The Wistar Institute have identified a previously unknown mechanism by which viruses can reprogram mitochondrial structure to silence immune responses and ensure successful viral ...

Dengue virus (DENV) is a global health threat, causing repeated epidemics throughout the tropical world. While low herd immunity levels to any one of the four antigenic types of DENV predispose ...

Toward the goal of efficient editing of farm animals for genetic improvements, this study explores an upgraded form of nuclease PE (uPEn). Based on the resolved structure of the NiV polymerase L-P ...

HBV is a partially double-stranded DNA virus. The life cycle and therapeutic targets are shown in Figure 1 and Figure 2. The spherical 42-nm virion comprises an envelope that is outside a 30-nm ...

“I’m a virus guy, for sure,” says Dr. Tamanash Bhattacharya, a postdoctoral fellow in the Malik Lab of the Fred Hutch Basic Sciences division, with a broad smile. The Malik Lab specializes in studying ...