The EMBO Journal1d
Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation
In 2020-2021, a mysterious skin disease affected fishermen in Senegal. High levels of Portimine A toxin, produced by the ...
The EMBO Journal4d
A CRISPR-Cas9 screen reveals genetic determinants of the cellular response to decitabine
A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...
The EMBO Journal10d
Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile
In patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting ...
The EMBO Journal4d
Proteogenomic analysis reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Aneuploidy is prevalent in cancer and ...
The EMBO Journal5d
Pharmacological CDK4/6 inhibition promotes vulnerability to lysosomotropic agents in breast cancer
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Breast cancer is a leading cause of mortality ...
The EMBO Journal9d
Microbial metabolites tune amygdala neuronal hyperexcitability and anxiety-linked behaviors
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Changes in gut microbiota composition have ...
The EMBO Journal5d
Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cancers display cellular, genetic and ...