The 'Learn to Code' era is over — as an AI editor, here's the 'Intent Architecture' roadmap I’m giving my kids instead

Coding is becoming a background task. Discover why the "syntax barrier" has vanished and the three orchestration skills I’m ...

The 'learn to code' era is officially over: Why I switched my kids to 'intent architecture' instead

As AI agents move from writing snippets to building entire systems, the $100k skill of the last decade is becoming a ...

The 50 best movies on HBO Max for dedicated cinephiles

Almost 100 years of cinema are represented on this list: starting with City Lights (1931) and extending all the way to 2026 ...
eLife

The Locomoting State Selectively Amplifies Activity of Sensitizing Neurons in Primary Visual Cortex

This manuscript presents a valuable analysis of how locomotion modulates the activity of different subtypes of cortical neurons in the mouse primary visual cortex, showing that locomotion more ...
eLife

Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state

The dorsal raphe nucleus (DRN) serotonergic (5-HT) system has been implicated in regulating sleep and motor control; however, its specific role remains controversial. In this study, we found that ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...