The universal features that define genomic regions acting as replication origins remain unclear. In this study, we mapped a set of origins in Trypanosoma brucei using stranded short nascent strand ...

"Adapt or perish, now as ever, is nature's inexorable imperative," wrote H. G. Wells. This principle—that survival requires ...

Cryo-EM revealed HIV-1 integrase’s distinct structures as it shifts between its two roles of DNA integration and RNA-binding.

Scripps Research scientists have discovered how some tumors endure DNA damage, revealing a potential new way to target them. The DNA inside our cells is constantly exposed to damage, and one of the ...

We have long struggled to determine how the first living organisms on Earth came together. Now, surprising evidence hints ...

The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.

GlobalData forecasts the hepatitis B therapeutics market will more than double to $3.2B by 2034, driven by functional cure ...

A new study reports that the locations where genes begin are particularly prone to mutations, and these genetic changes can ...

Since the human immunodeficiency virus (HIV) was identified in 1983, roughly 91.4 million people around the world have ...

Obelisks are <1 kb RNA replicators with protein-coding genes and ribozymes * Found in 50% of oral and 7% of gut microbiomes, indicating widespread presence * Their impact on //human health remains ...

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both ...