Kazia Therapeutics Limited: Kazia Therapeutics Announces Collaboration and In-Licensing Agreement for First-in-Class PD-L1 Protein Degrader Program

Kazia Therapeutics Limited (NASDAQ: KZIA), an oncology-focused drug development company, today announced an exclusive collaboration ...
The Malaysian Reserve

Kazia Therapeutics Announces Collaboration and In-Licensing Agreement for First-in-Class PD-L1 Protein Degrader Program

Kazia Therapeutics Limited (NASDAQ: KZIA), an oncology-focused drug development company, today announced an exclusive ...
Targeted Oncology

Phase 1b Data Suggest Paxalisib Combo May Suppress CTCs in Metastatic TNBC

A promising clinical trial shows that a combination of paxalisib, pembrolizumab, and chemotherapy significantly reduces circulating tumor cells in metastatic triple-negative breast cancer. Preliminary ...
Scientific Research Publishing

Miricescu, D., Totan, A., Stanescu-Spinu, I., Badoiu, S.C., Stefani, C. and Greabu, M. (2020) PI3k/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to ...

ABSTRACT: Abnormal cell division leading to chromosomal instability is a hallmark of cancer development. Accurate chromosome classification Lysis plays an important role in cell division, and the ...
Frontiers

Exploring the roles of ncRNAs in prostate cancer via the PI3K/AKT/mTOR signaling pathway

Although various treatment options are available for prostate cancer (PCa), including androgen deprivation therapy (ADT) and chemotherapy, these approaches have not achieved the desired results ...
Scientific Research Publishing

Li, J., Cheng, X., Fu, D., Liang, Y., Chen, C., Deng, W., et al. (2022) Autophagy of Spinal Microglia Affects the Activation of Microglia through the PI3K/AKT/mTOR Signaling ...

ABSTRACT: Background and Purpose: Spinal cord injury (SCI) manifests as a central nervous system disorder causing sensory and motor impairments. Preventing an overabundance of microglial activation is ...
C&EN

Dust Fall Microplastics from a Megacity of China Inhibit Autophagy via the PI3K/Akt/mTOR Pathway

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The problem of microplastics (MPs) pollution has caused many health risks to residents ...
C&EN

Potential Therapeutic Effect of Sinigrin on Diethylnitrosamine-Induced Liver Cancer in Mice: Exploring the Involvement of Nrf-2/HO-1, PI3K–Akt–mTOR Signaling Pathways, and ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Sinigrin is a glucosinolate present in plants of the family Brassicaceae and has been ...
Frontiers

Monocrotaline-mediated autophagy via inhibiting PI3K/AKT/mTOR pathway induces apoptosis in rat hepatocytes

Monocrotaline (MCT), a major pyrrolizidine alkaloid, is well-known for its high liver toxicity. Dysregulation of autophagy induced apoptosis can lead to various liver diseases, including those induced ...