Scripps Research scientists have discovered how some tumors endure DNA damage, revealing a potential new way to target them. The DNA inside our cells is constantly exposed to damage, and one of the ...

The universal features that define genomic regions acting as replication origins remain unclear. In this study, we mapped a set of origins in Trypanosoma brucei using stranded short nascent strand ...

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both ...

We have long struggled to determine how the first living organisms on Earth came together. Now, surprising evidence hints ...

"Adapt or perish, now as ever, is nature's inexorable imperative," wrote H. G. Wells. This principle—that survival requires ...

Obelisks are <1 kb RNA replicators with protein-coding genes and ribozymes * Found in 50% of oral and 7% of gut microbiomes, indicating widespread presence * Their impact on //human health remains ...

Cryo-EM revealed HIV-1 integrase’s distinct structures as it shifts between its two roles of DNA integration and RNA-binding.

The rate of HIV infection continues to climb globally. Around 40 million people live with HIV-1, the most common HIV strain. While symptoms can now be better managed with lifelong treatment, there is ...