How hippocampal synapses adjust their proteins to specialize their function

A research team led by Dr. Àlex Bayés, Head of the Molecular Physiology of the Synapse Group at the Institut de Recerca Sant ...

Structure Therapeutics Reports Positive Topline Data from ACCESS Program for its Once-Daily Oral Small Molecule GLP-1 Receptor Agonist, Aleniglipron

Placebo-adjusted mean weight loss of 11.3% (27.3 lbs) with 120 mg dose in the 36-week Phase 2b ACCESS study with a 10.4% adverse event-related ...

How anti-epilepsy drugs alter a key brain protein structure

A multi-institute team led by St. Jude Children's Research Hospital and UT Southwestern Medical Center investigators ...
Technology Networks

Cryo-EM Reveals How Epilepsy Drugs Engage Neuronal Protein SV2A

Using cryo-electron microscopy, researchers have visualized how widely used epilepsy drugs bind and reshape the neuronal ...
IEEE

Characterizing Secretion System Effector Proteins With Structure-Aware Graph Neural Networks and Pre-Trained Language Models

Abstract: The Type III Secretion Systems (T3SSs) play a pivotal role in host-pathogen interactions by mediating the secretion of type III secretion system effectors (T3SEs) into host cells. These ...