BMJ1d
Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination
Objectives To determine whether the process of ubiquitination and/or activity of the 26S proteasome are involved in the induction of osteoarthritis (OA). Methods Bovine cartilage resorption assays, ...
BMJ2d
AB0694 The efficacy and safety of abatacept (orencia) in patients with active juvenile idiopathic arthritis (jia).
Background From 2009 Abatacept (ABA) – a new generation biological DMARD was approved in Russia. ABA selectively modulates T-cell activation, which seems to play the key role in the pathogenesys of ...
BMJ3d
FRI0115 Humira® (Adalimumab): Fifteen Years of Controlled Production and Consistency of Quality Attributes
Background Biologics, in particular monoclonal antibodies (mAbs), transformed treatment of autoimmune diseases such as rheumatoid arthritis (RA) by selectively targeting pathogenesis and modifying ...
BMJ4d
HLA-B27 associated spondyloarthropathy, an autoimmune disease based on crossreactivity between bacteria and HLA-B27?
Academic Medical Centre, University of Amsterdam, Department of Medical Microbiology, the Netherlands Dr J H Ringrose, Department of Medical Microbiology, Academic Medical Centre, AMC L1–160, PO Box ...
BMJ5d
Impact of treatment with biologic DMARDs on the risk of sepsis or mortality after serious infection in patients with rheumatoid arthritis
Objective This observational cohort study investigated the impact of biological (b) disease-modifying antirheumatic drugs (DMARDs) on the outcomes of serious infections (SIs) in patients with ...
BMJ5d
Adalimumab for steroid sparing in patients with giant-cell arteritis: results of a multicentre randomised controlled trial
7 National Referral Centre for Rare Systemic Auto-immune Diseases, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France Objectives To evaluate the effect of adding a 10-week treatment of ...
BMJ5d
Baseline predictors of different types of treatment success in rheumatoid arthritis
Objective To perform a comprehensive analysis on predictors of achieving disease activity outcomes by change, response and state measures. Methods We used data from three rheumatoid arthritis (RA) ...
BMJ5d
OP0020 Identification of Multiple Sjögren’s Syndrome Susceptibility Loci
Background Sjögren’s syndrome (SS) is a common, clinically heterogeneous autoimmune disease characterized by exocrine gland dysfunction that involves both innate and adaptive immune responses. A ...
BMJ5d
The anti-inflammatory effects of sympathectomy in murine antigen-induced arthritis are associated with a reduction of Th1 and Th17 responses
1 Institute of Pathology, University Hospital, Friedrich Schiller University, Jena, Germany 2 Institute of Physiology I, University Hospital, Friedrich Schiller University, Jena, Germany Background ...
BMJ6d
AB0285 EFFECTIVENESS OF IMMUNOSUPPRESSIVE THERAPY FOR CONNECTIVE TISSUE DISEASE–ASSOCIATED PULMONARY ARTERIAL HYPERTENSION
1 Graduate School of Medicine, The University of Tokyo, Department of Cardiovascular Medicine, Tokyo, Japan 2 Graduate School of Medicine, The University of Tokyo., Department of Therapeutic Strategy ...